Description
Human SHOC2 Recombinant Protein (N-His)
Human SHOC2 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ser86-Val582, with an N-terminal His tag. Predicted molecular weight: 58.15 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Leucine-rich repeat protein SHOC-2 (SHOC2) is a ~64 kDa protein. Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates activation of the MAPK pathway. For research use only.
Acts as a scaffolding protein in the SMP complex. The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities. The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c.
| Product Name: | Human SHOC2 Recombinant Protein (N-His) |
| SKU: | GXRP04447 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Leucine-rich repeat protein SHOC-2, KIAA0862, Protein sur-8 homolog, Protein soc-2 homolog, SHOC2 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Ser86-Val582 |
| Calculated MW: | 58.15 kDa |
| UniProt: | Q9UQ13 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
