Description
Human SMAD7 Recombinant Protein (N-His)
Human SMAD7 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-Arg426, with an N-terminal His tag. Predicted molecular weight: 48.59 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. SMAD family member 7 (SMAD7) is a ~46 kDa protein. Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. For research use only.
Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
| Product Name: | Human SMAD7 Recombinant Protein (N-His) |
| SKU: | GXRP00100 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Mothers against decapentaplegic homolog 8, MADH8, SMAD family member 7, MADH7, SMAD 7, Mothers against decapentaplegic homolog 7, Smad7, hSMAD7, Mothers against DPP homolog 7, SMAD7, Mothers against DPP homolog 8, MAD homolog 8, MAD homolog 7 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-Arg426 |
| Calculated MW: | 48.59 kDa |
| UniProt: | O15105 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
