Description
Human SRGAP2 Recombinant Protein (N-His)
Human SRGAP2 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Thr494-Phe679, with an N-terminal His tag. Predicted molecular weight: 23.51 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. SLIT-ROBO Rho GTPase-activating protein 2 is a ~120 kDa protein. Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex. For research use only.
Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons. SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses. Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation. Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions.
| Product Name: | Human SRGAP2 Recombinant Protein (N-His) |
| SKU: | GXRP11843 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | ARHGAP34, FNBP2, Formin-binding protein 2, KIAA0456, Rho GTPase-activating protein 34, SLIT-ROBO Rho GTPase-activating protein 2, SRGAP2, SRGAP2A, srGAP2 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Thr494-Phe679 |
| Calculated MW: | 23.51 kDa |
| UniProt: | O75044 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
