Description
Human STK3 Recombinant Protein (N-His)
Human STK3 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ser15-Asn280, with an N-terminal His tag. Predicted molecular weight: 32.32 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Serine/threonine-protein kinase 3 (STK3) is a ~56 kDa protein. Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. For research use only.
Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation.
| Product Name: | Human STK3 Recombinant Protein (N-His) |
| SKU: | GXRP04791 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | STK3, MST2/N, MST-2, STE20-like kinase MST2, Mammalian STE20-like protein kinase 2, Serine/threonine-protein kinase Krs-1, Serine/threonine-protein kinase 3, KRS1, MST2, MST2/C |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Ser15-Asn280 |
| Calculated MW: | 32.32 kDa |
| UniProt: | Q13188 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
