Description
Human SYNE2 Recombinant Protein (N-His)
Human SYNE2 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Glu6-Asp263, with an N-terminal His tag. Predicted molecular weight: 31.65 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Nesprin-2 (SYNE2) is a ~796 kDa protein. Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. For research use only.
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrosome attachment.
| Product Name: | Human SYNE2 Recombinant Protein (N-His) |
| SKU: | GXRP02638 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Nuclear envelope spectrin repeat protein 2, KIAA1011, Protein NUANCE, KASH domain-containing protein 2, Nesprin-2, Syne-2, NUA, SYNE2, Synaptic nuclear envelope protein 2, Nucleus and actin connecting element protein, KASH2 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Glu6-Asp263 |
| Calculated MW: | 31.65 kDa |
| UniProt: | Q8WXH0 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
