Description
Human TANK Recombinant Protein (N-His)
Human TANK Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Leu131-Ile369, with an N-terminal His tag. Predicted molecular weight: 28.89 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. TRAF family member-associated NF-kappa-B activator (TANK) is a ~47 kDa protein. Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. For research use only.
Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage. Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage.
| Product Name: | Human TANK Recombinant Protein (N-His) |
| SKU: | GXRP02663 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | I-TRAF, TRAF family member-associated NF-kappa-B activator, TANK, ITRAF, TRAF-interacting protein, TRAF2 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Leu131-Ile369 |
| Calculated MW: | 28.89 kDa |
| UniProt: | Q92844 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
