Description
Human TRAC Recombinant Protein (N-His)
Human TRAC Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ile1-Ser140, with an N-terminal His tag. Predicted molecular weight: 18.01 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. T cell receptor alpha chain constant is a ~15 kDa protein. Constant region of T cell receptor (TR) alpha chain. For research use only.
Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome.
| Product Name: | Human TRAC Recombinant Protein (N-His) |
| SKU: | GXRP11787 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | T cell receptor alpha chain constant, TCRA, TRAC |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Ile1-Ser140 |
| Calculated MW: | 18.01 kDa |
| UniProt: | P01848 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
