Description
Human TRAF4 Recombinant Protein (N-His)
Human TRAF4 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Gln193-Asp444, with an N-terminal His tag. Predicted molecular weight: 30.71 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. TNF receptor-associated factor 4 (TRAF4) is a ~53 kDa protein. Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis. For research use only.
Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation. Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation. Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair. In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction.
| Product Name: | Human TRAF4 Recombinant Protein (N-His) |
| SKU: | GXRP02811 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | CART1, MLN62, RING finger protein 83, TRAF4, MLN 62, Cysteine-rich domain associated with RING and Traf domains protein 1, RNF83, Metastatic lymph node gene 62 protein, TNF receptor-associated factor 4 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Gln193-Asp444 |
| Calculated MW: | 30.71 kDa |
| UniProt: | Q9BUZ4 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
