Description
Human TRPC4AP Recombinant Protein (N-His)
Human TRPC4AP Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Leu427-Lys511, with an N-terminal His tag. Predicted molecular weight: 11.93 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Short transient receptor potential channel 4-associated protein (TRPC4AP) is a ~90 kDa protein. Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control. For research use only.
The DCX(TRPC4AP) complex specifically mediates the polyubiquitination and subsequent degradation of MYC as part of the DesCEND (destruction via C-end degrons) pathway. The DesCEND (destruction via C-end degrons) pathway recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The DCX(TRPC4AP) complex specifically recognizes proteins with an arginine at the minus 3 position (R-3 motif) at the C-terminus, such as MYC, leading to their ubiquitination and degradation. Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome.
| Product Name: | Human TRPC4AP Recombinant Protein (N-His) |
| SKU: | GXRP04704 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | Trp4-associated protein, Protein TRUSS, C20orf188, Protein TAP1, Short transient receptor potential channel 4-associated protein, TRRP4AP, TRPC4AP, Trpc4-associated protein, TNF-receptor ubiquitous scaffolding/signaling protein |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Leu427-Lys511 |
| Calculated MW: | 11.93 kDa |
| UniProt: | Q8TEL6 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
