Description
Human UBQLN2 Recombinant Protein (N-GST)
Human UBQLN2 Recombinant Protein (N-GST) is a recombinant protein expressed in E. coli, spanning Ile33-Ala126, with an N-terminal GST tag. Predicted molecular weight: 37.15 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Ubiquilin-2 (UBQLN2) is a ~65 kDa protein. Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. For research use only.
Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome. Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome. Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion. Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs).
| Product Name: | Human UBQLN2 Recombinant Protein (N-GST) |
| SKU: | GXRP03023 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | N4BP4, UBQLN2, Ubiquilin-2, Ubiquitin-like product Chap1/Dsk2, DSK2 homolog, PLIC-2, hPLIC-2, PLIC2, Protein linking IAP with cytoskeleton 2, Chap1 |
| Tag: | N-GST |
| Expression Host: | E. coli |
| Protein Length: | Ile33-Ala126 |
| Calculated MW: | 37.15 kDa |
| UniProt: | Q9UHD9 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
