Description
Human VHL Recombinant Protein (N-His)
Human VHL Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Glu70-Asp213, with an N-terminal His tag. Predicted molecular weight: 19.02 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. von Hippel-Lindau disease tumor suppressor (VHL) is a ~24 kDa protein. Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. For research use only.
Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2. Acts as a negative regulator of mTORC1 by promoting ubiquitination and degradation of RPTOR.
| Product Name: | Human VHL Recombinant Protein (N-His) |
| SKU: | GXRP04731 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | VHL, pVHL, Protein G7, von Hippel-Lindau disease tumor suppressor |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Glu70-Asp213 |
| Calculated MW: | 19.02 kDa |
| UniProt: | P40337 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
