Description
Human WIPI2 Recombinant Protein (N-His)
Human WIPI2 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Met1-Arg374, with an N-terminal His tag. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. WD repeat domain phosphoinositide-interacting protein 2 is a ~49 kDa protein. Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. For research use only.
Involved in an early step of the formation of preautophagosomal structures. Binds and is activated by phosphatidylinositol 3-phosphate (PtdIns3P) forming on membranes of the endoplasmic reticulum upon activation of the upstream ULK1 and PI3 kinases. Mediates ER-isolation membranes contacts by interacting with the ULK1:RB1CC1 complex and PtdIns3P. Once activated, WIPI2 recruits at phagophore assembly sites the ATG12-ATG5-ATG16L1 complex that directly controls the elongation of the nascent autophagosomal membrane.
| Product Name: | Human WIPI2 Recombinant Protein (N-His) |
| SKU: | GXRP13637 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | WD repeat domain phosphoinositide-interacting protein 2, WIPI-2, WIPI2, WIPI49-like protein 2 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-Arg374 |
| UniProt: | Q9Y4P8 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only |
