Description
Human YTHDC2 Recombinant Protein (N-His)
Human YTHDC2 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Glu185-Gly361, with an N-terminal His tag. Predicted molecular weight: 22.39 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. 3'-5' RNA helicase YTHDC2 is a ~160 kDa protein. 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells. Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non-coding RNAs that plays a role in the efficiency of RNA processing and stability. For research use only.
Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs. Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease. Required for both spermatogenesis and oogenesis.
| Product Name: | Human YTHDC2 Recombinant Protein (N-His) |
| SKU: | GXRP04454 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Human |
| Synonyms: | YTHDC2, hYTHDC2, YTH domain-containing protein 2, 3'-5' RNA helicase YTHDC2 |
| Tag: | N-His |
| Expression Host: | E. coli |
| Protein Length: | Glu185-Gly361 |
| Calculated MW: | 22.39 kDa |
| UniProt: | Q9H6S0 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
