Anti-INHA Antibody (CAB1734)

Antibody Name:	Anti-INHA Antibody
Antibody SKU:	CAB1734
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 19-366 of human INHA (NP_002182.1).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Mouse, Rat
Positive Samples:	Rat testis

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 19-366 of human INHA (NP_002182.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	CQGL ELAR ELVL AKVR ALFL DALG PPAV TREG GDPG VRRL PRRH ALGG FTHR GSEP EEEE DVSQ AILF PATD ASCE DKSA ARGL AQEA EEGL FRYM FRPS QHTR SRQV TSAQ LWFH TGLD RQGT AASN SSEP LLGL LALS PGGP VAVP MSLG HAPP HWAV LHLA TSAL SLLT HPVL VLLL RCPL CTCS ARPE ATPF LVAH TRTR PPSG GERA RRST PLMS WPWS PSAL RLLQ RPPE EPAA HANC HRVA LNIS FQEL GWER WIVY PPSF IFHY CHGG CGLH IPPN LSLP VPGA PPTP AQPY SLLP GAQP CCAA LPGT MRPL HVRT TSDG GYSF KYET VPNL LTQH CACI
Gene ID:	3623
Uniprot:	P05111
Cellular Location:	Secreted
Calculated MW:	39kDa
Observed MW:	40kDa

Synonyms:

INHA

Background:

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. Mutations in this gene may be associated with male infertility and premature ovarian failure in female human patients.

UniProt Protein Function:	INHA: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family.
UniProt Protein Details:	Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 2q35 Cellular Component: extracellular region Molecular Function:cytokine activity; growth factor activity; hormone activity; protein binding; receptor binding; transforming growth factor beta receptor binding Biological Process: cell cycle arrest; cell development; cell differentiation; cell surface receptor linked signal transduction; cell-cell signaling; hemoglobin biosynthetic process; negative regulation of B cell differentiation; negative regulation of cell cycle; negative regulation of interferon-gamma biosynthetic process; negative regulation of macrophage differentiation; negative regulation of phosphorylation; positive regulation of follicle-stimulating hormone secretion; regulation of apoptosis; regulation of cell cycle; regulation of cell proliferation; regulation of MAPKKK cascade; response to external stimulus; signal transduction; skeletal development
NCBI Summary:	This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate multiple peptide products, including the alpha subunit of the inhibin A and B protein complexes. These complexes negatively regulate follicle stimulating hormone secretion from the pituitary gland. Inhibins have also been implicated in regulating numerous cellular processes including cell proliferation, apoptosis, immune response and hormone secretion. Mutations in this gene may be associated with male infertility and premature ovarian failure in female human patients. [provided by RefSeq, Aug 2016]
UniProt Code:	P05111
NCBI GenInfo Identifier:	124274
NCBI Gene ID:	3623
NCBI Accession:	P05111.1
UniProt Secondary Accession:	P05111,A8K8H5,
UniProt Related Accession:	P05111
Molecular Weight:	39,670 Da
NCBI Full Name:	Inhibin alpha chain
NCBI Synonym Full Names:	inhibin alpha subunit
NCBI Official Symbol:	INHA
NCBI Protein Information:	inhibin alpha chain
UniProt Protein Name:	Inhibin alpha chain
Protein Family:	Inhibin
UniProt Gene Name:	INHA

	Western blot analysis of extracts of rat testis, using INHA antibody (CAB1734) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST.
	Immunohistochemistry of paraffin-embedded rat brain using INHA antibody (CAB1734) at dilution of 1:200 (40x lens).

ELISA Kits

Human Inhibin A ELISA Kit

Human INHA (Inhibin A) CLIA Kit (HUES00184)

Human INHA (Inhibin A) ELISA Kit (HUES01484)

Human Inhibin alpha chain (INHA) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)