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Anti-IP3R Antibody (CAB4436)

SKU:
CAB4436
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ACV
CLA4
INSP3R1
IP3R
IP3R1
PPP1R94
SCA15
SCA16
SCA29
Research Area:
Cell Death
  • Cell Death Antibodies 2 Anti-IP3R Antibody CAB4436
  • Cell Death Antibodies 2 Anti-IP3R Antibody CAB4436
€139 - €419
Frequently bought together:

Description

Product Name:IP3R Rabbit mAb
Product Code:CAB4436
Size:20uL, 50uL, 100uL
Synonyms:ACV, CLA4, INSP3R1, IP3R, IP3R1, PPP1R94, SCA15, SCA16, SCA29
Applications:WB, IHC, IF
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human IP3R
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Mouse, Rat
Positive Samples:Mouse brain
Immunogen:A synthesized peptide derived from human IP3R
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3708
Uniprot:Q14643
Cellular Location:Endoplasmic reticulum membrane, Multi-pass membrane protein
Calculated MW:314kDa
Observed MW:320KDa
UniProt Protein Function:IP3R1: a multi-pass endoplasmic reticulum membrane receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaMKII, eventually leading to the activation of downstream apoptosis pathways. Part of a cGMP kinase signaling complex that includes alpha-actin, calponin H1, phospholamban, PKG1 and IP3R1. Widely expressed. The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylation by PKA prevents the ligand-induced opening of the calcium channels. Belongs to the ryanodine-inositol 1,4,5-triphosphate receptor ca(2+) channel (rir-cac) family. Eight alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:Channel, ligand-gated; Channel, calcium; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p26.1

Cellular Component: calcineurin complex; endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; membrane; nuclear inner membrane; nucleolus; platelet dense granule membrane; postsynaptic density; sarcoplasmic reticulum

Molecular Function:calcium channel inhibitor activity; calcium ion transmembrane transporter activity; inositol 1,4,5-triphosphate-sensitive calcium-release channel activity; intracellular ligand-gated calcium channel activity; phosphoinositide binding; protein binding

Biological Process: blood coagulation; calcium ion transport; endoplasmic reticulum calcium ion homeostasis; energy reserve metabolic process; epidermal growth factor receptor signaling pathway; epithelial fluid transport; fibroblast growth factor receptor signaling pathway; innate immune response; inositol phosphate-mediated signaling; negative regulation of calcium-mediated signaling; nerve growth factor receptor signaling pathway; phospholipase C activation; platelet activation; post-embryonic development; regulation of insulin secretion; release of sequestered calcium ion into cytosol; response to hypoxia; signal transduction; stimulatory C-type lectin receptor signaling pathway; vascular endothelial growth factor receptor signaling pathway; voluntary musculoskeletal movement

NCBI Summary:This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009]
UniProt Code:Q14643
NCBI GenInfo Identifier:519668682
NCBI Gene ID:3708
NCBI Accession:Q14643.3
UniProt Secondary Accession:Q14643,Q14660, Q99897, E7EPX7, E9PDE9,
UniProt Related Accession:Q14643
Molecular Weight:
NCBI Full Name:Inositol 1,4,5-trisphosphate receptor type 1
NCBI Synonym Full Names:inositol 1,4,5-trisphosphate receptor type 1
NCBI Official Symbol:ITPR1  
NCBI Official Synonym Symbols:ACV; CLA4; IP3R; IP3R1; SCA15; SCA16; SCA29; INSP3R1; PPP1R94  
NCBI Protein Information:inositol 1,4,5-trisphosphate receptor type 1
UniProt Protein Name:Inositol 1,4,5-trisphosphate receptor type 1
UniProt Synonym Protein Names:IP3 receptor isoform 1; IP3R 1; InsP3R1; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor
Protein Family:Inositol 1,4,5-trisphosphate receptor
UniProt Gene Name:ITPR1  
UniProt Entry Name:ITPR1_HUMAN

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