JNK3 Polyclonal Antibody (CAB2112)
- SKU:
- CAB2112
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | JNK3 Polyclonal Antibody |
| Product Code: | CAB2112 |
| Reactivity: | Mouse |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Mouse |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Positive Samples: | Mouse brain, Mouse testis |
| Cellular Location: | Cytoplasm, Lipid-anchor, Membrane, Mitochondrion, Nucleus |
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 175-464 of human JNK3 (NP_620448.1). |
| Sequence: | CGIKH LHSAG IIHRD LKPSN IVVKS DCTLK ILDFG LARTA GTSFM MTPYV VTRYY RAPEV ILGMG YKENV DIWSV GCIMG EMVRH KILFP GRDYI DQWNK VIEQL GTPCP EFMKK LQPTV RNYVE NRPKY AGLTF PKLFP DSLFP ADSEH NKLKA SQARD LLSKM LVIDP AKRIS VDDAL QHPYI NVWYD PAEVE APPPQ IYDKQ LDERE HTIEE WKELI YKEVM NSEEK TKNGV VKGQP SPSGA AVNSS ESLPP SSSVN DISSM STDQT LASDT DSSLE ASAGP LGCCR |
| Synonyms: | JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK |
| Calculated MW: | 44kDa |
| Observed MW: | 48kDa |
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