Anti-KLK5 Antibody (CAB2991)

Antibody Name:	Anti-KLK5 Antibody
Antibody SKU:	CAB2991
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	A synthetic peptide of human KLK5

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	Mouse testis, Mouse heart, Mouse liver

Immunogen:	A synthetic peptide of human KLK5
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	25818
Uniprot:	Q9Y337
Cellular Location:	Secreted
Calculated MW:	32kDa
Observed MW:	32kDa

Synonyms:

KLK5, KLK-L2, KLKL2, SCTE

Background:

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein.

UniProt Protein Function:	KLK5: May be involved in desquamation. Belongs to the peptidase S1 family. Kallikrein subfamily.
UniProt Protein Details:	Protein type:EC 3.4.21.-; Protease; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 19q13.33 Cellular Component: extracellular space Molecular Function:peptidase activity; protein binding; serine-type peptidase activity; serine-type endopeptidase activity Biological Process: epidermis development; positive regulation of G-protein coupled receptor protein signaling pathway; proteolysis
NCBI Summary:	Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
UniProt Code:	Q9Y337
NCBI GenInfo Identifier:	296434569
NCBI Gene ID:	25818
NCBI Accession:	Q9Y337.2
UniProt Secondary Accession:	Q9Y337,Q53ZR3, Q9HBG8,
UniProt Related Accession:	Q9Y337
Molecular Weight:	293
NCBI Full Name:	Kallikrein-5
NCBI Synonym Full Names:	kallikrein-related peptidase 5
NCBI Official Symbol:	KLK5
NCBI Official Synonym Symbols:	SCTE; KLKL2; KLK-L2
NCBI Protein Information:	kallikrein-5; kallikrein 5; kallikrein-like protein 2; stratum corneum tryptic enzyme
UniProt Protein Name:	Kallikrein-5
UniProt Synonym Protein Names:	Kallikrein-like protein 2; KLK-L2; Stratum corneum tryptic enzyme
Protein Family:	Kallikrein
UniProt Gene Name:	KLK5
UniProt Entry Name:	KLK5_HUMAN

	Western blot analysis of extracts of various cell lines, using KLK5 antibody (CAB2991) at 1:400 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
	Immunohistochemistry of paraffin-embedded rat kidney using KLK5 antibody (CAB2991) at dilution of 1:200 (40x lens).
	Immunohistochemistry of paraffin-embedded human liver cancer using KLK5 antibody (CAB2991) at dilution of 1:200 (40x lens).

Antibodies	ELISA Kits
Anti-KLK5 Antibody (CAB14863)	Human Kallikrein-5 (KLK5) ELISA Kit
KLK5 Antibody (PACO10144)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)