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Anti-KCNAB2 Antibody (CAB16224)

SKU:
CAB16224
Product Type:
Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction
  • Signal Transduction Antibodies 2 Anti-KCNAB2 Antibody CAB16224
  • Signal Transduction Antibodies 2 Anti-KCNAB2 Antibody CAB16224
€139 - €419
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Description

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Antibody Name:Anti-KCNAB2 Antibody
Antibody SKU:CAB16224
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-40 of human KCNAB2 (NP_003627.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-40 of human KCNAB2 (NP_003627.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MYPE STTG SPAR LSLR QTGS PGMI YSTR YGSP KRQL QFYR
Gene ID:8514
Uniprot:Q13303
Cellular Location:
Calculated MW:33kDa/39kDa/41kDa/43kDa/46kDa
Observed MW:46kDa
Synonyms:KCNAB2, AKR6A5, HKvbeta2, HKvbeta2.1, HKvbeta2.2, KCNA2B, KV-BETA-2
Background:Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
NCBI Summary:Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Dec 2010]
UniProt Code:Q13303
NCBI GenInfo Identifier:18202496
NCBI Gene ID:8514
NCBI Accession:Q13303.2
UniProt Related Accession:Q13303
Molecular Weight:33kDa; 39kDa; 41kDa; 43kDa; 46kDa
NCBI Full Name:Voltage-gated potassium channel subunit beta-2
NCBI Synonym Full Names:potassium voltage-gated channel subfamily A regulatory beta subunit 2
NCBI Official Symbol:KCNAB2  
NCBI Official Synonym Symbols:AKR6A5; KCNA2B; HKvbeta2; KV-BETA-2; HKvbeta2.1; HKvbeta2.2  
NCBI Protein Information:voltage-gated potassium channel subunit beta-2
UniProt Protein Name:Voltage-gated potassium channel subunit beta-2
UniProt Synonym Protein Names:K(+) channel subunit beta-2; Kv-beta-2
Protein Family:Voltage-gated potassium channel
UniProt Gene Name:KCNAB2  
UniProt Entry Name:KCAB2_HUMAN
Anti-KCNAB2 Antibody (CAB16224)Western blot analysis of extracts of various cell lines, using KCNAB2 antibody (CAB16224) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
Anti-KCNAB2 Antibody (CAB16224)Immunofluorescence analysis of L929 cells using KCNAB2 antibody (CAB16224) at dilution of 1:100. Blue: DAPI for nuclear staining.

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