Description
KCNE2 Antibody (CAB9859)
The KCNE2 Antibody (CAB9859) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blotting and immunofluorescence applications.KCNE2 is known to modulate the activity of potassium channels in cardiac muscle cells, impacting the duration and amplitude of action potentials. Dysregulation of KCNE2 has been linked to cardiac arrhythmias and other heart-related disorders, making it a promising target for therapeutic intervention.
This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human, Mouse samples.
| Product Name: | KCNE2 Antibody |
| SKU: | CAB9859 |
| Size: | 20μL, 100μL |
| Reactivity: | Human, Mouse |
| Conjugate: | Unconjugated |
| Immunogen: | Synthetic peptide. This information is considered to be commercially sensitive. | ||||
| Sequence: | MSTL SNFT QTLE DVFR RIFI TYMD NWRQ NTTA EQEA LQAK VDAE NFYY VILY LMVM IGMF SFII VAIL VSTV KSKR REHS NDPY HQYI VEDW QEKY KSQI | ||||
| Tested Applications: | WB ELISA | ||||
| Recommended Dilution: |
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| Synonyms: | LQT5, LQT6, ATFB4, MIRP1, KCNE2 |
| Positive Sample: | U-251MG |
| Cellular Localization: | Cell Membrane, Single-Pass Type I Membrane Protein. |
| Calculated MW: | 14kDa |
| Observed MW: | 15kDa |
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia.
| Purification Method | Affinity purification |
| Gene ID | 9992 |
| RRID | AB_2770047 |
| Buffer Information | Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3. |
 | Western blot analysis of lysates from U-251MG cells, using KCNE2 Rabbit pAb (CAB9859) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 90s. |
