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Western blot analysis of various lysates, using KCNN3/SK3 Rabbit mAb antibody (CAB23419) at 1:2000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST.
Key Features

KCNN3/SK3 Monoclonal Antibody (CAB23419)

Datasheet MSDS
SKU CAB23419
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Rat
Host Species Rabbit
Synonyms SK3, ZLS3, hSK3, SKCA3, KCa2.3, KCNN3/SK3
$173 - $603

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Description

system_update_altDatasheetsystem_update_altMSDS

KCNN3/SK3 Monoclonal Antibody (CAB23419)

The KCNN3/SK3 Monoclonal Antibody (CAB23419) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody specifically targets the KCNN3/SK3 protein, which is involved in the modulation of calcium-activated potassium channels.Raised in mice, this monoclonal antibody is highly specific and sensitive to human samples, making it ideal for use in various research applications such as immunofluorescence, immunoprecipitation, and flow cytometry. By targeting the KCNN3/SK3 protein, researchers can effectively study its function and its potential implications in diseases related to ion channel dysregulation.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Rat samples.

Product Name:KCNN3/SK3 Monoclonal Antibody
SKU:CAB23419
Size:20μL, 100μL
Reactivity:Rat
Clone Number:ARC60792
Conjugate:Unconjugated
Immunogen:Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Sequence:Email for sequence
Tested Applications:WB ELISA
Recommended Dilution:
WB1:1000 - 1:4000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:SK3, ZLS3, hSK3, SKCA3, KCa2.3, KCNN3/SK3
Positive Sample:Rat brain
Cellular Localization:Membrane, Multi-Pass Membrane Protein.
Calculated MW:81kDa
Observed MW:81kDa

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. This gene belongs to the KCNN family of potassium channels. It encodes an integral membrane protein that forms a voltage-independent calcium-activated channel, which is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene contains two CAG repeat regions in the coding sequence. It was thought that expansion of one or both of these repeats could lead to an increased susceptibility to schizophrenia or bipolar disorder, but studies indicate that this is probably not the case. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Purification MethodAffinity purification
Gene ID3782
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of lysates from Rat brain using KCNN3/SK3 Rabbit mAb (CAB23419) at 1:2000 dilution incubated overnight at 4℃. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 30 s.
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