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Anti-KHDRBS2 Antibody (CAB6102)

SKU:
CAB6102
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
  • Epigenetics and Nuclear Signaling Antibodies 2 Anti-KHDRBS2 Antibody CAB6102
  • Epigenetics and Nuclear Signaling Antibodies 2 Anti-KHDRBS2 Antibody CAB6102
  • Epigenetics and Nuclear Signaling Antibodies 2 Anti-KHDRBS2 Antibody CAB6102
  • Epigenetics and Nuclear Signaling Antibodies 2 Anti-KHDRBS2 Antibody CAB6102
€139 - €419
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Description

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Antibody Name:Anti-KHDRBS2 Antibody
Antibody SKU:CAB6102
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human KHDRBS2 (NP_689901.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:1000 IHC 1:100 - 1:200
Reactivity:Human, Mouse
Positive Samples:HeLa, 293T, Jurkat, K-562
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human KHDRBS2 (NP_689901.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TAPS RGRG GAIP PPPP PGRG VLTP RGST VTRG ALPV PPVA RGVP TPRA RGAP TVPG YRAP PPPA HEAY EEYG YDDG YGGE YDDQ TYET YDNS YATQ TQSV PEYY DYGH GVSE DAYD SYAP EEWA TTRS SLKA PPQR SARG GYRE HPYG RY
Gene ID:202559
Uniprot:Q5VWX1
Cellular Location:Nucleus
Calculated MW:38kDa
Observed MW:39kDa
Synonyms:KHDRBS2, SLM-1, SLM1
Background:
UniProt Protein Function:KHDRBS2: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. May function as an adapter protein for Src kinases during mitosis. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability. Belongs to the KHDRBS family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 6q11.1

Cellular Component: nucleoplasm

Molecular Function:protein binding

UniProt Code:Q5VWX1
NCBI GenInfo Identifier:74762274
NCBI Gene ID:202559
NCBI Accession:Q5VWX1.1
UniProt Secondary Accession:Q5VWX1,Q8N4I4, Q8TCZ4, A8K7M8,
UniProt Related Accession:Q5VWX1
Molecular Weight:38,927 Da
NCBI Full Name:KH domain-containing, RNA-binding, signal transduction-associated protein 2
NCBI Synonym Full Names:KH RNA binding domain containing, signal transduction associated 2
NCBI Official Symbol:KHDRBS2  
NCBI Official Synonym Symbols:SLM1; SLM-1  
NCBI Protein Information:KH domain-containing, RNA-binding, signal transduction-associated protein 2
UniProt Protein Name:KH domain-containing, RNA-binding, signal transduction-associated protein 2
UniProt Synonym Protein Names:Sam68-like mammalian protein 1; SLM-1; hSLM-1
Protein Family:KH domain-containing, RNA-binding, signal transduction-associated protein
UniProt Gene Name:KHDRBS2  
UniProt Entry Name:KHDR2_HUMAN
Anti-KHDRBS2 Antibody (CAB6102)Western blot analysis of extracts of various cell lines, using KHDRBS2 antibody (CAB6102) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 30s.
Anti-KHDRBS2 Antibody (CAB6102)Immunohistochemistry of paraffin-embedded human prostate cancer using KHDRBS2 antibody (CAB6102) at dilution of 1:100 (40x lens).
Anti-KHDRBS2 Antibody (CAB6102)Immunohistochemistry of paraffin-embedded human esophagus using KHDRBS2 antibody (CAB6102) at dilution of 1:100 (40x lens).
Anti-KHDRBS2 Antibody (CAB6102)Immunohistochemistry of paraffin-embedded human stomach using KHDRBS2 antibody (CAB6102) at dilution of 1:100 (40x lens).

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