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[KO Validated] CSK Rabbit Polyclonal Antibody (CAB0735)

SKU:
CAB0735
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology
  • KO Validated Antibodies 1 Anti-CSK Antibody CAB0735KO Validated
  • KO Validated Antibodies 1 Anti-CSK Antibody CAB0735KO Validated
  • KO Validated Antibodies 1 Anti-CSK Antibody CAB0735KO Validated
  • KO Validated Antibodies 1 Anti-CSK Antibody CAB0735KO Validated
  • KO Validated Antibodies 1 Anti-CSK Antibody CAB0735KO Validated
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] CSK Rabbit Polyclonal Antibody
SKU:CAB0735
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CSK (NP_001120662.1).
Sequence:MSAI QAAW PSGT ECIA KYNF HGTA EQDL PFCK GDVL TIVA VTKD PNWY KAKN KVGR EGII PANY VQKR EGVK AGTK LSLM PWFH GKIT REQA ERLL YPPE TGLF LVRE STNY PGDY TLCV SCDG KVEH YRIM YHAS KLSI DEEV YFEN LMQL VEHY TSDA DGLC TRLI KPKV MEGT VAAQ DEFY RSGW ALNM KELK LLQT
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:1000
Synonyms:CSK
Positive Sample:A549,Mouse spleen
Conjugate:Unconjugated
Cellular Localization:Cell membrane, Cytoplasm.
Calculated MW:51kDa
Observed MW:51kDa

The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants.

Purification Method:Affinity purification
Gene ID:1445
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using CSK Rabbit pAb (CAB0735) at 1:1000 dilution.Secondary antibody:HRP Goat Anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection:ECL Enhanced Kit (AbGn00021).Exposuretime: 90s.

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