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Anti-GBP2 Antibody (CAB19874)[KO Validated]

SKU:
CAB19874
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Immunology
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Description

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Antibody Name:Anti-GBP2 Antibody [KO Validated]
Antibody SKU:CAB19874
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant protein of human GBP2.
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:A-549
Immunogen:Recombinant protein of human GBP2.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:2634
Uniprot:P32456
Cellular Location:Cytoplasm, Golgi apparatus membrane, Lipid-anchor, Membrane, perinuclear region
Calculated MW:67kDa
Observed MW:67KDa
Anti-GBP2 Antibody [KO Validated] (CAB19874)Western blot analysis of extracts from normal (control) and GBP2 knockout (KO) A-549 cells, using GBP2 antibody (CAB19874) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Synonyms:GBP2
Background:This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas.
UniProt Protein Function:GBP2: a member of the family of large GTP-binding proteins (GBPs) that is inducible by interferon. Possesses a high GTP hydrolysis activity. GBPs are the most abundant cellular proteins expressed in response to interferon-gamma (IFN-gamma). IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), and interleukin-1beta (IL-1beta) strongly induce the expression of GBP-1, -2, and -3.
UniProt Protein Details:

Protein type:Hydrolase; Vesicle

Chromosomal Location of Human Ortholog: 1p22.2

Cellular Component: cytosol

Molecular Function:protein binding

Biological Process: immune response

NCBI Summary:This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas. [provided by RefSeq, Jul 2013]
UniProt Code:P32456
NCBI GenInfo Identifier:226694187
NCBI Gene ID:2634
NCBI Accession:P32456.3
UniProt Secondary Accession:P32456,Q6GPH0, Q6IAU2, Q86TB0,
UniProt Related Accession:P32456
Molecular Weight:67,209 Da
NCBI Full Name:Guanylate-binding protein 2
NCBI Synonym Full Names:guanylate binding protein 2
NCBI Official Symbol:GBP2  
NCBI Protein Information:guanylate-binding protein 2
UniProt Protein Name:Guanylate-binding protein 2
UniProt Synonym Protein Names:GTP-binding protein 2; GBP-2; HuGBP-2; Guanine nucleotide-binding protein 2; Interferon-induced guanylate-binding protein 2
Protein Family:Guanylate-binding protein
UniProt Gene Name:GBP2  
UniProt Entry Name:GBP2_HUMAN

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