Anti-GRK2 [KO Validated] Antibody (CAB4443)
- SKU:
- CAB4443
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ADRBK1
- BARK1
- BETA-ARK1
- Research Area:
- Cell Biology
Description
| Product Name: | [KO Validated] GRK2 Rabbit mAb |
| Product Code: | CAB4443 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | ADRBK1, BARK1, BETA-ARK1 |
| Applications: | WB, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human GRK2 |
| Applications: | WB, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, Mouse brain, Mouse spleen, Rat brain |
| Immunogen: | A synthesized peptide derived from human GRK2 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 156 |
| Uniprot: | P25098 |
| Cellular Location: | Cell membrane, Cytoplasm |
| Calculated MW: | 80kDa |
| Observed MW: | 80KDa |
| UniProt Protein Function: | GRK2: a ubiquitous protein kinase of the GRK family. Phosphorylates the beta-2-adrenergic receptor and related G-protein-coupled receptors. Appears to mediate agonist-specific desensitization observed at high agonist concentrations. Expression level is consistently elevated in chronic human heart failure. Mouse models of severe heart failure have been used to demonstrate that inhibition of BARK1 with a peptide inhibitor is sufficient to increase mean survival, reduce dialation and improve cardiac function. |
| UniProt Protein Details: | Protein type:Kinase, protein; EC 2.7.11.15; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; AGC group; GRK family; BARK subfamily Chromosomal Location of Human Ortholog: 11q13.1 Cellular Component: membrane; cytoplasm; plasma membrane; cytosol Molecular Function:G-protein coupled receptor kinase activity; protein binding; Edg-2 lysophosphatidic acid receptor binding; beta-adrenergic receptor kinase activity; alpha-2A adrenergic receptor binding; ATP binding; protein kinase activity Biological Process: epidermal growth factor receptor signaling pathway; desensitization of G-protein coupled receptor protein signaling pathway; tachykinin signaling pathway; fibroblast growth factor receptor signaling pathway; acetylcholine receptor signaling, muscarinic pathway; nerve growth factor receptor signaling pathway; heart development; peptidyl-threonine phosphorylation; signal transduction; negative regulation of striated muscle contraction; peptidyl-serine phosphorylation; negative regulation of the force of heart contraction by chemical signal; phospholipase C activation; receptor internalization; positive regulation of catecholamine secretion; innate immune response; cardiac muscle contraction |
| NCBI Summary: | The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P25098 |
| NCBI GenInfo Identifier: | 126302521 |
| NCBI Gene ID: | 156 |
| NCBI Accession: | P25098.2 |
| UniProt Secondary Accession: | P25098,Q13837, Q6GTT3, B0ZBE1, |
| UniProt Related Accession: | P25098 |
| Molecular Weight: | |
| NCBI Full Name: | Beta-adrenergic receptor kinase 1 |
| NCBI Synonym Full Names: | adrenergic, beta, receptor kinase 1 |
| NCBI Official Symbol: | ADRBK1Â Â |
| NCBI Official Synonym Symbols: | GRK2; BARK1; BETA-ARK1Â Â |
| NCBI Protein Information: | beta-adrenergic receptor kinase 1; beta-ARK-1; G-protein coupled receptor kinase 2 |
| UniProt Protein Name: | Beta-adrenergic receptor kinase 1 |
| UniProt Synonym Protein Names: | G-protein coupled receptor kinase 2 |
| UniProt Gene Name: | ADRBK1Â Â |
| UniProt Entry Name: | ARBK1_HUMAN |
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