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[KO Validated] NF2 Rabbit Polyclonal Antibody (CAB0739)

SKU:
CAB0739
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • KO Validated Antibodies 1 Anti-NF2 Antibody CAB0739KO Validated
  • KO Validated Antibodies 1 Anti-NF2 Antibody CAB0739KO Validated
  • KO Validated Antibodies 1 Anti-NF2 Antibody CAB0739KO Validated
  • KO Validated Antibodies 1 Anti-NF2 Antibody CAB0739KO Validated
  • KO Validated Antibodies 1 Anti-NF2 Antibody CAB0739KO Validated
$167 - $503
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:[KO Validated] NF2 Rabbit Polyclonal Antibody
SKU:CAB0739
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 477-576 of human NF2 (NP_000259.1).
Sequence:TKPT YPPM NPIP APLP PDIP SFNL IGDS LSFD FKDT DMKR LSME IEKE KVEY MEKS KHLQ EQLN ELKT EIEA LKLK ERET ALDI LHNE NSDR GGSS KHNT
Tested Applications:WB IF/ICC IP ELISA
Recommended Dilution:WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells
Synonyms:ACN; SCH; BANF; merlin-1; F2
Positive Sample:PC-3,Mouse brain,Mouse testis,PC-12,C6,HeLa
Conjugate:Unconjugated
Cellular Localization:Cell projection, Cytoplasm, Cytoplasmic granule, Cytoplasmic side, Nucleus, Nucleus, Peripheral membrane protein, cytoskeleton, filopodium membrane, perinuclear region, ruffle membrane.
Calculated MW:70kDa
Observed MW:73kDa

This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that link cytoskeletal components with proteins in the cell membrane. The encoded protein is involved in regulation of contact-dependent inhibition of cell proliferation and functions in cell-cell adhesion and transmembrane signaling. The encoded protein has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics, and proteins involved in regulating ion transport. Disruption of this protein's function has been implicated in tumorigenesis and metastasis. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities.

Purification Method:Affinity purification
Gene ID:4771
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Product ImageWestern blot analysis of lysates from wild type (WT) and NF2 knockdown (KD) HeLa cells using [KD Validated] NF2 Rabbit pAb (CAB0739) at 1:1000 dilution incubated overnight at 4℃.Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L)(CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020)Exposure time: 180 s.

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