LDLR Rabbit Polyclonal Antibody (CAB14996)
- SKU:
- CAB14996
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | LDLR Rabbit Polyclonal Antibody |
SKU: | CAB14996 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 761-860 of human LDL Receptor (LDLR) (NP_000518.1). |
Sequence: | TVEI VTMS HQAL GDVA GRGN EKKP SSVR ALSI VLPI VLLV FLCL GVFL LWKN WRLK NINS INFD NPVY QKTT EDEV HICH NQDG YSYP SRQM VSLE DDVA |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | FH; FHC; FHCL1; LDLCQ2; LDL Receptor (LDLR) |
Positive Sample: | HeLa,HepG2,Mouse lung,Mouse liver,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cell surface, Early endosome, Endomembrane system, Golgi apparatus, Late endosome, Lysosome, Membrane, Single-pass type I membrane protein, clathrin-coated pit. |
Calculated MW: | 95kDa |
Observed MW: | 100-160kDa |
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. The encoded protein is normally bound at the cell membrane, where it binds low density lipoprotein/cholesterol and is taken into the cell. Lysosomes release the cholesterol, which is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 3949 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |