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Anti-LHX4 Antibody (CAB8072)

SKU:
CAB8072
Product Type:
Antibody
Applications:
WB
IHC
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Epigenetics and Nuclear Signaling
  • Epigenetics and Nuclear Signaling Antibodies 4 Anti-LHX4 Antibody CAB8072
  • Epigenetics and Nuclear Signaling Antibodies 4 Anti-LHX4 Antibody CAB8072
  • Epigenetics and Nuclear Signaling Antibodies 4 Anti-LHX4 Antibody CAB8072
€139 - €419
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Description

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Antibody Name:LHX4 Rabbit Polyclonal Antibody
Antibody SKU:CAB8072
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 121-390 of human LHX4 (NP_203129.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 121-390 of human LHX4 (NP_203129.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:NRQL ATGD EFYL MEDG RLVC KEDY ETAK QNDD SEAG AKRP RTTI TAKQ LETL KNAY KNSP KPAR HVRE QLSS ETGL DMRV VQVW FQNR RAKE KRLK KDAG RHRW GQFY KSVK RSRG SSKQ EKES SAED CGVS DSEL SFRE DQIL SELG HTNR IYGN VGDV TGGQ LMNG SFSM DGTG QSYQ DLRD GSPY GIPQ SPSS ISSL PSHA PLLN GLDY TVDS NLGI IAHA GQGV SQTL RAMA GGPT SDIS TGSS VGYP DFPT SPGS WLDE MDHP PF
Gene ID:89884
Uniprot:Q969G2
Cellular Location:Nucleus
Calculated MW:43kDa
Observed MW:43kDa
Synonyms:LHX4, CPHD4
Background:This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor involved in the control of differentiation and development of the pituitary gland. Mutations in this gene cause combined pituitary hormone deficiency 4.
UniProt Protein Function:LHX4: May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung. Defects in LHX4 are the cause of pituitary hormone deficiency combined type 4 (CPHD4); also known as short stature pituitary and cerebellar defects and small sella turcica. The disorder is characterized by short stature, pituitary and cerebellar defects, and small transverse depression crossing the midline on the superior surface of the body of the sphenoid bone which houses the pituitary gland. A chromosomal aberration involving LHX4 may be a cause of acute lymphoblastic leukemia. Translocation t(1;14)(q25;q32) with IGHG1.
UniProt Protein Details:

Protein type:Oncoprotein; DNA-binding

Chromosomal Location of Human Ortholog: 1q25.2

Molecular Function:protein binding

Disease: Pituitary Hormone Deficiency, Combined, 4

NCBI Summary:This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor involved in the control of differentiation and development of the pituitary gland. Mutations in this gene cause combined pituitary hormone deficiency 4. [provided by RefSeq, Dec 2010]
UniProt Code:Q969G2
NCBI GenInfo Identifier:209572644
NCBI Gene ID:89884
NCBI Accession:Q969G2.2
UniProt Secondary Accession:Q969G2,Q8NHE0, Q8NHM1, Q8TCJ1, Q8WWX2, Q969W2,
UniProt Related Accession:Q969G2
Molecular Weight:43,124 Da
NCBI Full Name:LIM/homeobox protein Lhx4
NCBI Synonym Full Names:LIM homeobox 4
NCBI Official Symbol:LHX4  
NCBI Official Synonym Symbols:CPHD4  
NCBI Protein Information:LIM/homeobox protein Lhx4
UniProt Protein Name:LIM/homeobox protein Lhx4
Protein Family:LIM/homeobox protein
UniProt Gene Name:LHX4  
UniProt Entry Name:LHX4_HUMAN
Anti-LHX4 Polyclonal Antibody (CAB8072)Western blot analysis of extracts of various cell lines, using LHX4 Antibody (CAB8072) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
Anti-LHX4 Polyclonal Antibody (CAB8072)Immunohistochemistry of paraffin-embedded human kidney cancer using LHX4 antibody (CAB8072) at dilution of 1:100 (40x lens).
Anti-LHX4 Polyclonal Antibody (CAB8072)Immunohistochemistry of paraffin-embedded mouse cancer using LHX4 antibody (CAB8072) at dilution of 1:100 (40x lens).

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