Anti-MAP2 Antibody (CAB2572)
- SKU:
- CAB2572
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-MAP2 Antibody |
| Antibody SKU: | CAB2572 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 260-559 of human MAP2 (NP_001034627.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | SH-SY5Y, U-87MG |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 260-559 of human MAP2 (NP_001034627.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DENS FSLN SSIS SSAR RTTR SEPI RRAG KSGT STPT TPGS TAIT PGTP PSYS SRTP GTPG TPSY PRTP HTPG TPKS AILV PSEK KVAI IRTP PKSP ATPK QLRL INQP LPDL KNVK SKIG STDN IKYQ PKGG QVRI LNKK IDFS KVQS RCGS KDNI KHSA GGGN VQIV TKKI DLSH VTSK CGSL KNIR HRPG GGRV KIES VKLD FKEK AQAK VGSL DNAH HVPG GGNV KIDS QKLN FREH AKAR VDHG AEII TQSP GRSS VASP RRLS NVSS SGSI NLLE SPQL ATLA EDVT AALA KQGL |
| Gene ID: | 4133 |
| Uniprot: | P11137 |
| Cellular Location: | Cytoplasm, cytoskeleton |
| Calculated MW: | 49kDa/58kDa/199kDa |
| Observed MW: | 70kDa |
| Synonyms: | MAP2, MAP2A, MAP2B, MAP2C, Map2 |
| Background: | This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. |
| UniProt Protein Function: | MAP2: a member of the microtubule-associated protein (MAP) family. Its exact function is unknown but MAPs appear to stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. Expressed at high levels in neural tissue and the prostate. Four alternatively spliced transcript variants have been reported. |
| UniProt Protein Details: | Protein type:Cytoskeletal; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 2q34-q35 Cellular Component: cell soma; cytoplasm; dendritic shaft; microtubule; microtubule associated complex; neuron projection; nucleolus Molecular Function:calmodulin binding; microtubule binding; protein binding; structural molecule activity Biological Process: axonogenesis; central nervous system neuron development; dendrite morphogenesis; microtubule bundle formation; microtubule cytoskeleton organization and biogenesis; neurite development |
| NCBI Summary: | This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010] |
| UniProt Code: | P11137 |
| NCBI GenInfo Identifier: | 215274255 |
| NCBI Gene ID: | 4133 |
| NCBI Accession: | P11137.4 |
| UniProt Secondary Accession: | P11137,Q17S04, Q8IUX2, Q99975, Q99976, |
| UniProt Related Accession: | P11137 |
| Molecular Weight: | |
| NCBI Full Name: | Microtubule-associated protein 2 |
| NCBI Synonym Full Names: | microtubule associated protein 2 |
| NCBI Official Symbol: | MAP2Â Â |
| NCBI Official Synonym Symbols: | MAP2A; MAP2B; MAP2CÂ Â |
| NCBI Protein Information: | microtubule-associated protein 2 |
| UniProt Protein Name: | Microtubule-associated protein 2 |
| Protein Family: | Microtubule-associated protein |
| UniProt Gene Name: | MAP2Â Â |
| UniProt Entry Name: | MTAP2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using MAP2 antibody (CAB2572) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 5min. |
 | Immunohistochemistry of paraffin-embedded rat heart using MAP2 Antibody (CAB2572) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human kidney cancer using MAP2 Antibody (CAB2572) at dilution of 1:200 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using MAP2 Antibody (CAB2572) at dilution of 1:200 (40x lens). |
 | Immunofluorescence analysis of Mouse brain cells using MAP2 antibody (CAB2572) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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