JNK3 Polyclonal Antibody (CAB17408)
- SKU:
- CAB17408
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | JNK3 Polyclonal Antibody |
| Product Code: | CAB17408 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:2000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Positive Samples: | mouse testis, rat testis |
| Cellular Location: | Cytoplasm, Lipid-anchor, Membrane, Mitochondrion, Nucleus |
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system, and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human JNK3 (NP_620448.1). |
| Sequence: | NRPKY AGLTF PKLFP DSLFP ADSEH NKLKA SQARD LLSKM LVIDP AKRIS VDDAL QHPYI NVWYD PAEVE APPPQ IYDKQ LDERE HTIEE WKELI YKEVM N |
| Synonyms: | JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK |
| Calculated MW: | 44kDa |
| Observed MW: | 52kDa |
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