null

Anti-MED15 Antibody (CAB18238)

SKU:
CAB18238
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-MED15 Antibody
Antibody SKU:CAB18238
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant protein of human MED15.
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse heart, Mouse brain, Rat heart, Rat brain
Immunogen:Recombinant protein of human MED15.
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:51586
Uniprot:Q96RN5
Cellular Location:
Calculated MW:87kDa
Observed MW:87kDa
Anti-MED15 Antibody (CAB18238)Western blot - MED15 Polyclonal Antibody (CAB18238)
Synonyms:MED15, ARC105, CAG7A, CTG7A, PCQAP, TIG-1, TIG1, TNRC7
Background:The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:PCQAP: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway. Belongs to the Mediator complex subunit 15 family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 22q11.2

Cellular Component: nucleoplasm; membrane; cytoplasm; Srb-mediator complex; nucleus

Molecular Function:protein binding

Biological Process: regulation of transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; stem cell maintenance; gene expression

NCBI Summary:The protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator in RNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
UniProt Code:Q96RN5
NCBI GenInfo Identifier:119623361
NCBI Gene ID:51586
NCBI Accession:EAX02956.1
UniProt Secondary Accession:Q96RN5,O15413, Q6IC31, Q8NF16, Q96CT0, Q96IH7, Q9P1T3 D3DX31, D3DX32,
UniProt Related Accession:Q96RN5
Molecular Weight:86,753 Da
NCBI Full Name:PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein, isoform CRA_d
NCBI Synonym Full Names:mediator complex subunit 15
NCBI Official Symbol:MED15  
NCBI Official Synonym Symbols:TIG1; CAG7A; CTG7A; PCQAP; TIG-1; TNRC7; ARC105  
NCBI Protein Information:mediator of RNA polymerase II transcription subunit 15; TPA inducible gene-1; CTG repeat protein 7a; TPA inducible protein; TPA-inducible gene 1 protein; trinucleotide repeat containing 7; activator-recruited cofactor, 105-kD; PC2-glutamine-rich-associated protein; PC2 glutamine/Q-rich-associated protein; activator-recruited cofactor 105 kDa component; trinucleotide repeat-containing gene 7 protein; positive cofactor 2 glutamine/Q-rich-associated protein; positive cofactor 2, glutamine/Q-rich-associated protein; PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein
UniProt Protein Name:Mediator of RNA polymerase II transcription subunit 15
UniProt Synonym Protein Names:Activator-recruited cofactor 105 kDa component; ARC105; CTG repeat protein 7a; Mediator complex subunit 15; Positive cofactor 2 glutamine/Q-rich-associated protein; PC2 glutamine/Q-rich-associated protein; TPA-inducible gene 1 protein; TIG-1; Trinucleotide repeat-containing gene 7 protein
UniProt Gene Name:MED15  
UniProt Entry Name:MED15_HUMAN

Related Products