MEF2D (Phospho-Ser444) Transcription Factor Activity Assay

Product Name:	MEF2D (Phospho-Ser444) Transcription Factor Activity Assay
Product Code:	TFAB00055
Target:	MEF2D (Phospho-Ser444)
Reactivity:	Human, Mouse, Rat
Sample Types:	Nuclear or cell lysates

The Assay Genie MEF2D (Phospho-Ser444) transcription factor activity assay allows for the detection and qualitative analysis of MEF2D (Phospho-Ser444) active transcription factors in eukaryotic nuclear or cell lysates.

Assay Genie ELISA kits are designed to significantly reduce experiment time and ensure sensitivity and flexibility for high-throughput screening.

Assay Time:	4.5 hours
Detection Method:	Colorimetric 450 nm
Size:	12 x 8-Well Microstrips
Storage:	4°C for 6 months

UniProt Protein Function:	MEF2D: transcription factor which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. May be involved in muscle-specific and/or growth factor-related transcription. Six splice-variant isoforms have been described.
UniProt Protein Details:	Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 1q12-q23 Cellular Component: cytoplasm; intracellular membrane-bound organelle; nucleoplasm; nucleus Molecular Function:histone deacetylase binding; protein binding; protein heterodimerization activity; protein homodimerization activity; transcription activator binding; transcription factor activity Biological Process: adult heart development; apoptosis; chondrocyte differentiation; endochondral ossification; muscle development; nervous system development; osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter
NCBI Summary:	This gene is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
UniProt Code:	Q14814
NCBI GenInfo Identifier:	2500876
NCBI Gene ID:	4209
NCBI Accession:	Q14814.1
UniProt Secondary Accession:	Q14814,Q14815, Q5T9U5, Q5T9U6, D3DVC0,
UniProt Related Accession:	Q14814
Molecular Weight:	49,856 Da
NCBI Full Name:	Myocyte-specific enhancer factor 2D
NCBI Synonym Full Names:	myocyte enhancer factor 2D
NCBI Official Symbol:	MEF2D
NCBI Protein Information:	myocyte-specific enhancer factor 2D
UniProt Protein Name:	Myocyte-specific enhancer factor 2D
Protein Family:	Myocyte-specific enhancer factor
UniProt Gene Name:	MEF2D
UniProt Entry Name:	MEF2D_HUMAN

Antibodies

Anti-MEF2D Antibody (CAB16398)

Phospho-MEF2D (S444) Antibody (PACO02899)

MEF2D Antibody (PACO04319)

MEF2D Antibody (PACO50478)

MEF2D Antibody, HRP conjugated (PACO50479)