Monoamine Oxidase B (MAOB) Monoclonal Antibody (CAB11597)
The Monoamine Oxidase B (MAOB) Monoclonal Antibody (CAB11597) is a high-quality antibody developed for reliable detection and analysis of target proteins. This high-quality antibody, developed through immunization of rabbits, exhibits exceptional specificity and sensitivity for detecting MAO-B in human samples, making it an invaluable tool for studies in neuroscience and drug development.MAO-B is a key player in the breakdown of neurotransmitters like dopamine and serotonin, affecting mood, cognition, and behavior. Dysregulation of MAO-B activity has been linked to conditions such as Parkinson's disease, depression, and Alzheimer's disease, making it a promising target for therapeutic interventions.
This antibody is validated for use in WB, IHC-P, ELISA applications and has demonstrated reactivity against Human, Mouse, Rat samples.
Product Name:
Monoamine Oxidase B (MAOB) Monoclonal Antibody
SKU:
CAB11597
Size:
20μL, 100μL
Reactivity:
Human, Mouse, Rat
Clone Number:
ARC0641
Conjugate:
Unconjugated
Immunogen:
Synthetic peptide. This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
MAOB, monoamine oxidase B, Monoamine Oxidase B (MAOB)
Positive Sample:
HeLa, Hep G2
Cellular Localization:
Cytoplasmic Side, Mitochondrion Outer Membrane, Single-Pass Type Iv Membrane Protein.
Calculated MW:
59kDa
Observed MW:
59kDa
The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine.
Purification Method
Affinity purification
Gene ID
4129
RRID
AB_2861605
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates using Monoamine Oxidase B (MAOB) Rabbit mAb (CAB11597) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25 μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 10s.
Immunohistochemistry analysis of paraffin-embedded Human colon carcinoma tissue using Monoamine Oxidase B (MAOB) Rabbit mAb (CAB11597) at a dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
Immunohistochemistry analysis of paraffin-embedded Human liver tissue using Monoamine Oxidase B (MAOB) Rabbit mAb (CAB11597) at a dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
Immunohistochemistry analysis of paraffin-embedded Human tonsil tissue using Monoamine Oxidase B (MAOB) Rabbit mAb (CAB11597) at a dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate buffer (pH 6.0) prior to IHC staining.
