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Anti-MORF4L1 Antibody (CAB7071)

SKU:
CAB7071
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
  • Epigenetics and Nuclear Signaling Antibodies 4 Anti-MORF4L1 Antibody CAB7071
  • Epigenetics and Nuclear Signaling Antibodies 4 Anti-MORF4L1 Antibody CAB7071
€139 - €419
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Description

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Antibody Name:Anti-MORF4L1 Antibody
Antibody SKU:CAB7071
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human MORF4L1 (NP_006782.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:MCF-7, HepG2, THP-1, Mouse brain, Mouse spleen, Mouse testis, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-100 of human MORF4L1 (NP_006782.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAPK QDPK PKFQ EGER VLCF HGPL LYEA KCVK VAIK DKQV KYFI HYSG WNKN WDEW VPES RVLK YVDT NLQK QREL QKAN QEQY AEGK MRGA APGK KTSG
Gene ID:10933
Uniprot:Q9UBU8
Cellular Location:Nucleus
Calculated MW:26kDa/37kDa/41kDa
Observed MW:41kDa
Synonyms:MORF4L1, Eaf3, FWP006, HsT17725, MEAF3, MORFRG15, MRG15, S863-6
Background:
UniProt Protein Function:MORF4L1: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 15q24

Cellular Component: nucleoplasm; NuA4 histone acetyltransferase complex; Sin3 complex

Molecular Function:protein binding; protein N-terminus binding; chromatin binding

Biological Process: cell proliferation; establishment and/or maintenance of chromatin architecture; regulation of transcription, DNA-dependent; transcription, DNA-dependent; regulation of growth; histone deacetylation; double-strand break repair via homologous recombination

UniProt Code:Q9UBU8
NCBI GenInfo Identifier:59803121
NCBI Gene ID:10933
NCBI Accession:Q9UBU8.2
UniProt Secondary Accession:Q9UBU8,O95899, Q5QTS1, Q6NVX8, Q86YT7, Q9HBP6, Q9NSW5 B4DKN6, B7Z6R1, D3DW88,
UniProt Related Accession:Q9UBU8
Molecular Weight:362
NCBI Full Name:Mortality factor 4-like protein 1
NCBI Synonym Full Names:mortality factor 4 like 1
NCBI Official Symbol:MORF4L1  
NCBI Official Synonym Symbols:Eaf3; MEAF3; MRG15; FWP006; S863-6; HsT17725; MORFRG15  
NCBI Protein Information:mortality factor 4-like protein 1; protein MSL3-1; MORF-related gene 15 protein; Esa1p-associated factor 3 homolog; MORF-related gene on chromosome 15; transcription factor-like protein MRG15
UniProt Protein Name:Mortality factor 4-like protein 1
UniProt Synonym Protein Names:MORF-related gene 15 protein; Protein MSL3-1; Transcription factor-like protein MRG15
Protein Family:Mortality factor 4-like protein
UniProt Gene Name:MORF4L1  
UniProt Entry Name:MO4L1_HUMAN
Anti-MORF4L1 Antibody (CAB7071)Western blot analysis of extracts of various cell lines, using MORF4L1 antibody (CAB7071) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s.
Anti-MORF4L1 Antibody (CAB7071)Immunofluorescence analysis of MCF7 cells using MORF4L1 antibody (CAB7071). Blue: DAPI for nuclear staining.

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