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APC Anti-Mouse CD117 Antibody [2B8] (AGEL1184)

Datasheet MSDS
SKU AGEL1184
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Mouse
Applications FC
$112 - $289

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Description

system_update_altDatasheetsystem_update_altMSDS

APC Anti-Mouse CD117 Antibody [2B8]

The Mouse CD117 Monoclonal Antibody (APC Conjugated, 2B8) is a vital tool for researchers investigating CD117, a cell surface marker commonly used to identify and isolate hematopoietic stem cells and progenitor cells. This monoclonal antibody, derived from mouse sources, exhibits a high affinity for CD117 and is conjugated to allophycocyanin (APC) for easy detection in flow cytometry applications.CD117, also known as c-kit or stem cell factor receptor, is a transmembrane protein involved in various cellular processes, including cell survival, proliferation, and differentiation.

Its expression pattern makes it a key target for studies in hematopoiesis, oncology, and regenerative medicine. By specifically recognizing CD117, this antibody enables precise analysis of cell populations expressing this important marker, facilitating advancements in stem cell research, cancer therapy, and other fields requiring precise identification of CD117-positive cells.

Product Title:APC Anti-Mouse CD117 Antibody [2B8]
SKU:AGEL1184
Size:50 Tests, 100 Tests, 200 Tests
Clone No:2B8
Synonyms:Mast/stem cell growth factor receptor Kit;Kit;SCFR;Proto-oncogene c-Kit;Tyrosine-protein kinase Kit;CD117;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:APC Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P05532
Gene ID:16590
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD117 is a 145 kD immunoglobulin superfamily member also known as c-Kit and stem cell factor receptor (SCFR). It is a transmembrane tyrosine-kinase receptor that binds the c-Kit ligand (also known as steel factor, stem cell factor, and mast cell growth factor). CD117 is expressed on hematopoietic stem cells (including multipotent hematopoietic stem cells, progenitors committed to myeloid and/or erythroid lineages, and T and B cell precursors), mast cells, and acute myeloid leukemia (AML) cells. CD117 interaction with its ligand is critical for the development of hematopoietic stem cells.

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