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APC Anti-Mouse CD206 Antibody [C068C2] (AGEL1653)

Datasheet MSDS
SKU AGEL1653
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Mouse
Applications FC
€113 - €238

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Description

system_update_altDatasheetsystem_update_altMSDS

APC Anti-Mouse CD206 Antibody [C068C2]

The Mouse CD206 Monoclonal Antibody APC-Conjugated (C068C2-AGEL1653) from Assay Genie is a powerful tool for researchers studying CD206, a cell surface receptor with key roles in immune regulation and inflammation. This monoclonal antibody, derived from mouse hybridomas, is optimized for use in flow cytometry applications, allowing precise and reliable detection of CD206 in mouse samples.CD206, also known as mannose receptor, is a crucial component of the immune system, involved in antigen uptake and presentation, as well as modulation of immune responses. By targeting CD206 with this specific and high-affinity APC-conjugated antibody, researchers can investigate the expression and function of CD206 in various cell types and experimental conditions.

This antibody is a valuable asset for studies focusing on immunology, infectious diseases, and cancer research, where CD206 is implicated in pathogenesis and therapeutic interventions. Through targeted detection of CD206, researchers can gain insights into the role of this receptor in immune signaling pathways, offering potential avenues for the development of novel treatments and immunotherapies.Overall, the Mouse CD206 Monoclonal Antibody APC-Conjugated (C068C2-AGEL1653) provides researchers with a reliable and specific tool for investigating the intricate functions of CD206 in the context of immune regulation and disease pathogenesis.

Product Title:APC Anti-Mouse CD206 Antibody [C068C2]
SKU:AGEL1653
Size:50 Tests, 100 Tests, 200 Tests
Clone No:C068C2
Synonyms:MMR;MR;MRC1;macrophage mannose receptor;mannose receptor ;
Host Species:Rat
Reactivity:Mouse
Application:FCM;ICFCM
Isotype:Rat IgG2a, κ
Isotype Control:APC Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q61830
Gene ID:17533
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity. Recently, MR on lymphatic endothelial cells was found to be involved in leukocyte trafficking and a contributor to the metastatic behavior of cancer cells. It suggests that MR may be a potential target in controlling inflammation and cancer metastasis by targeting the lymphatic vasculature.
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