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Mouse CD26/DPP4 Recombinant Protein (N-His)
Key Features

Mouse CD26/DPP4 Recombinant Protein (N-His) (GXRP05960)

SKU GXRP05960
Product Type Recombinant Protein
Species Mouse
Expression System E. coli
Tag N-His
$458 - $2,412

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Description

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Mouse CD26/DPP4 Recombinant Protein (N-His)

Mouse CD26/DPP4 Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Gln502-His760, with an N-terminal His tag. Predicted molecular weight: 31.80 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Dipeptidyl peptidase 4 (CD26/DPP4) is a ~87 kDa protein. Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. For research use only.

Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM.

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