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APC Anti-Mouse CD8a Antibody [53-6.7] (AGEL0382)

Datasheet MSDS
SKU AGEL0382
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Mouse
Host Species Rat
Isotype IgG2a
Clone 53.6.7
Conjugation APC
Applications FC
$37 - $115

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Description

system_update_altDatasheetsystem_update_altMSDS

APC Anti-Mouse CD8a Antibody [53-6.7]

The Mouse CD8a Monoclonal Antibody (APC-conjugated, clone 53-6.7, AGEL0382) from Assay Genie is a powerful tool for research involving the CD8a molecule, an essential component of the immune system's response to pathogens and cancer cells.This high-quality antibody, derived from a mouse hybridoma cell line, specifically targets the CD8a protein, aiding in its detection and characterization in various experimental settings. The APC conjugation provides the antibody with fluorescence properties, enabling easy visualization and analysis in flow cytometry and immunofluorescence assays.CD8a, also known as the CD8 antigen, is a co-receptor expressed on cytotoxic T cells and plays a critical role in antigen recognition and T cell activation.

Its involvement in immune responses and surveillance makes it a key target for investigations in immunology, infectious diseases, and cancer immunotherapy.By utilizing the Mouse CD8a Monoclonal Antibody (APC-conjugated, clone 53-6.7, AGEL0382), researchers can enhance their studies on T cell biology, immune responses, and immunotherapy strategies aimed at harnessing the power of cytotoxic T cells in combating diseases. Trust in Assay Genie's reliable reagents to advance your research in immunology and beyond.

Product Title:APC Anti-Mouse CD8a Antibody [53-6.7]
SKU:AGEL0382
Size:50 Tests, 100 Tests, 200 Tests
Clone No:53-6.7
Synonyms:T-cell surface glycoprotein CD8 alpha chain;CD8A;T-lymphocyte differentiation antigen T8/Leu-2;MAL;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:APC Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P01731
Gene ID:12525
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.
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