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APC Anti-Mouse MHC II (I-A/I-E) Antibody [M5/114] (AGEL0022)

Datasheet MSDS
SKU AGEL0022
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Mouse
Host Species Rat
Isotype IgG2b
Clone M5/114
Conjugation APC
Applications FC
€43 - €109

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Description

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APC Anti-Mouse MHC II (I-A/I-E) Antibody [M5/114]

The APC-Conjugated Mouse I-A/I-E Monoclonal Antibody (M5/114) is designed for in-depth research involving I-A/I-E, critical molecules within the Major Histocompatibility Complex (MHC) class II system, essential for antigen presentation and immune response activation. This monoclonal antibody, produced in mice, is highly specific to mouse I-A/I-E and validated for use in flow cytometry applications. Its conjugation with allophycocyanin (APC) provides bright and stable red fluorescence, ensuring precise detection and reliable results.I-A/I-E molecules play a pivotal role in the adaptive immune response by presenting antigens to CD4+ T cells. Their significance in immune regulation makes them valuable targets for research into autoimmune disorders, chronic inflammatory conditions, and infectious diseases.

The APC-Conjugated Mouse I-A/I-E Monoclonal Antibody (M5/114) is essential for researchers aiming to delve into the mechanisms of antigen presentation and develop therapies that modulate immune function.By enabling accurate and sensitive detection of I-A/I-E molecules, this antibody supports comprehensive studies of immune response pathways, contributing to the development of novel therapeutic strategies for autoimmune diseases and other immune-related conditions. Understanding the activity of I-A/I-E is crucial for creating innovative immunotherapies that leverage or modulate antigen presentation in various disease contexts. This antibody is an indispensable tool for advancing immunology and cancer research.

Product Title:APC Anti-Mouse MHC II (I-A/I-E) Antibody [M5/114]
SKU:AGEL0022
Size:50 Tests, 100 Tests, 200 Tests
Clone No:M5/114
Synonyms:H2-Ab1/Eb1;Major histocompatibility protein class II beta chain;MHC class II H2-IA-beta-psi;I-E beta MHC class II;MHC class II;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:APC Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:APC
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P14483 O78196
Gene ID:14961,14969
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:These class II molecules are expressed on antigen presenting cells (including B cells) and a subset of T cells from H-2b,d,q,r bearing mice and are involved in antigen presentation to T cells expressing CD3/TCR and CD4 proteins.
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