Description
Mouse PPP2R1A Recombinant Protein (C-His)
Mouse PPP2R1A Recombinant Protein (C-His) is a recombinant protein expressed in E. coli, spanning Met1-Ala589, with a C-terminal His tag. Predicted molecular weight: 66.38 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PPP2R1A) is a ~65 kDa protein. The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. For research use only.
Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT. Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis. Together with RACK1 adapter, mediates dephosphorylation of AKT1 at 'Ser-473', preventing AKT1 activation and AKT-mTOR signaling pathway. Dephosphorylation of AKT1 is essential for regulatory T-cells (Treg) homeostasis and stability.
| Product Name: | Mouse PPP2R1A Recombinant Protein (C-His) |
| SKU: | GXRP07041 |
| Size: | 50 µg, 100 µg, 1 mg |
| Species: | Mouse |
| Synonyms: | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, PP2A subunit A isoform PR65-alpha, PP2A subunit A isoform R1-alpha, Ppp2r1a |
| Tag: | C-His |
| Expression Host: | E. coli |
| Protein Length: | Met1-Ala589 |
| Calculated MW: | 66.38 kDa |
| UniProt: | Q76MZ3 |
| Applications: | ELISA, Immunogen, SDS-PAGE, WB |
| Purity: | >90% as determined by SDS-PAGE. |
| Form: | Lyophilized |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. |
| Reconstitution: | Reconstitute in sterile water for a stock solution. Adjust the volume of sterile water so that, after reconstitution, the final stock concentration matches the value indicated on the product label or datasheet. |
| Storage: | Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. |
| Shipping: | In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. |
| Note: | For research use only. |
