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Mouse TG/Thyroglobulin Recombinant Protein (N-His)
Key Features

Mouse TG/Thyroglobulin Recombinant Protein (N-His) (GXRP06980)

SKU GXRP06980
Product Type Recombinant Protein
Species Mouse
Expression System E. coli
Tag N-His
$458 - $2,412

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Description

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Mouse TG/Thyroglobulin Recombinant Protein (N-His)

Mouse TG/Thyroglobulin Recombinant Protein (N-His) is a recombinant protein expressed in E. coli, spanning Ser2418-Asn2660, with an N-terminal His tag. Predicted molecular weight: 29.33 kDa. Purity: >90% as determined by SDS-PAGE. Supplied lyophilized from a solution in PBS pH 7.4, 1 mM EDTA, 4% Trehalose, 1% Mannitol. Applications: ELISA, immunogen, SDS-PAGE and Western blot. Thyroglobulin is a ~304 kDa protein. Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). For research use only.

The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling. Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream (Probable). One dimer produces 7 thyroid hormone molecules.

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