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Anti-MTMR4 Antibody (CAB15349)

SKU:
CAB15349
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology
  • Cell Biology Antibodies 6 Anti-MTMR4 Antibody CAB15349
  • Cell Biology Antibodies 6 Anti-MTMR4 Antibody CAB15349
  • Cell Biology Antibodies 6 Anti-MTMR4 Antibody CAB15349
€139 - €419
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Description

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Antibody Name:Anti-MTMR4 Antibody
Antibody SKU:CAB15349
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 920-1195 of human MTMR4 (NP_004678.3).
Application:WB IF
Recommended Dilution:WB 1:200 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:293T, HepG2, Mouse brain, Mouse liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 920-1195 of human MTMR4 (NP_004678.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GEAT PRRL LSYG CCSK RPNS KQMR ATGP CFGG QWAQ REGV KSPV CSSH SNGH CTGP GGKN QMWL SSHP KQVS STKP VPLN CPSP VPPL YLDD DGLP FPTD VIQH RLRQ IEAG YKQE VEQL RRQV RELQ MRLD IRHC CAPP AEPP MDYE DDFT CLKE SDGS DTED FGSD HSED CLSE ASWE PVDK KETE VTRW VPDH MASH CYNC DCEF WLAK RRHH CRNC GNVF CAGC CHLK LPIP DQQL YDPV LVCN SCYE HIQV SRAR ELMS QQLK KPIA TASS
Gene ID:9110
Uniprot:Q9NYA4
Cellular Location:Cytoplasm, Membrane, Peripheral membrane protein
Calculated MW:133kDa
Observed MW:133kDa
Synonyms:MTMR4, FYVE-DSP2, ZFYVE11
Background:
UniProt Protein Function:MTMR4: Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3). Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.
UniProt Protein Details:

Protein type:Motility/polarity/chemotaxis; EC 3.1.3.48; Phosphatase, lipid; Protein phosphatase, tyrosine (non-receptor); Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: 17q22

Cellular Component: cytosol; early endosome membrane; extracellular space

Molecular Function:phosphatidylinositol-3-phosphatase activity; protein binding; protein serine/threonine phosphatase activity

Biological Process: negative regulation of transforming growth factor beta receptor signaling pathway; phosphatidylinositol biosynthetic process; protein amino acid dephosphorylation

UniProt Code:Q9NYA4
NCBI GenInfo Identifier:296438298
NCBI Gene ID:9110
NCBI Accession:Q9NYA4.2
UniProt Secondary Accession:Q9NYA4,Q8IV27, Q9Y4D5, D3DTZ6,
UniProt Related Accession:Q9NYA4
Molecular Weight:133,353 Da
NCBI Full Name:Myotubularin-related protein 4
NCBI Synonym Full Names:myotubularin related protein 4
NCBI Official Symbol:MTMR4  
NCBI Official Synonym Symbols:ZFYVE11; FYVE-DSP2  
NCBI Protein Information:myotubularin-related protein 4
UniProt Protein Name:Myotubularin-related protein 4
UniProt Synonym Protein Names:FYVE domain-containing dual specificity protein phosphatase 2; FYVE-DSP2; Zinc finger FYVE domain-containing protein 11
Protein Family:Myotubularin-related protein
UniProt Gene Name:MTMR4  
UniProt Entry Name:MTMR4_HUMAN
Anti-MTMR4 Antibody (CAB15349)Western blot analysis of extracts of various cell lines, using MTMR4 antibody (CAB15349) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
Anti-MTMR4 Antibody (CAB15349)Immunofluorescence analysis of L929 cells using MTMR4 Polyclonal Antibody (CAB15349) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
Anti-MTMR4 Antibody (CAB15349)Immunofluorescence analysis of U-2 OS cells using MTMR4 Polyclonal Antibody (CAB15349) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.

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