The MMRN1 Antibody (CAB6658) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced in rabbits, exhibits high specificity and sensitivity to human Multimerin-1, making it a reliable choice for Western blot applications.Multimerin-1 is important in the regulation of hemostasis and thrombosis, and its dysregulation has been linked to various bleeding disorders and cardiovascular diseases. By targeting Multimerin-1 with this antibody, researchers can explore its role in these physiological processes and potentially identify new therapeutic targets for clotting disorders.Furthermore, the Multimerin-1 Polyclonal Antibody (CAB6658) offers researchers the opportunity to investigate Multimerin-1's potential involvement in cancer progression, as aberrant expression of this protein has been observed in certain cancer types.
This antibody is validated for use in WB, IF/ICC, ELISA applications and has demonstrated reactivity against Human, Mouse samples.
Product Name:
MMRN1 Antibody
SKU:
CAB6658
Size:
20μL, 100μL
Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Immunogen:
Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:
ECM, MMRN, GPIa*, EMILIN4, MMRN1
Positive Sample:
HepG2, U-251MG, Mouse lung, Mouse spleen
Cellular Localization:
Secreted.
Calculated MW:
138kDa
Observed MW:
180kDa
Multimerin is a massive, soluble protein found in platelets and in the endothelium of blood vessels. It is comprised of subunits linked by interchain disulfide bonds to form large, variably sized homomultimers. Multimerin is a factor V/Va-binding protein and may function as a carrier protein for platelet factor V. It may also have functions as an extracellular matrix or adhesive protein. Recently, patients with an unusual autosomal-dominant bleeding disorder (factor V Quebec) were found to have a deficiency of platelet multimerin.
Purification Method
Affinity purification
Gene ID
22915
RRID
AB_2767245
Buffer Information
Store at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol, preserved with proclin300 or sodium azide, pH 7.3.
Western blot analysis of various lysates, using MMRN1 Rabbit pAb (CAB6658) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Negative control (NC):U-251 MG Exposure time: 180s.
Immunofluorescence analysis of U2OS cells using MMRN1 Rabbit pAb (CAB6658). Secondary antibody: Cy3-conjugated Goat anti-Rabbit IgG (H+L) (CABS007) at 1:500 dilution. Blue: DAPI for nuclear staining.
