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Anti-MYBBP1A Antibody (CAB4429)

SKU:
CAB4429
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
MYBBP1A
P160
PAP2
Pol5
Research Area:
Cell Biology
  • Cell Biology Antibodies 9 Anti-MYBBP1A Antibody CAB4429
  • Cell Biology Antibodies 9 Anti-MYBBP1A Antibody CAB4429
  • Cell Biology Antibodies 9 Anti-MYBBP1A Antibody CAB4429
  • Cell Biology Antibodies 9 Anti-MYBBP1A Antibody CAB4429
€139 - €419
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Description

Product Name:MYBBP1A Rabbit pAb
Product Code:CAB4429
Size:20uL, 50uL, 100uL
Synonyms:MYBBP1A, P160, PAP2, Pol5
Applications:WB, IHC, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1104-1328 of human MYBBP1A (NP_055335.2).
Applications:WB, IHC, IF
Recommended Dilutions:WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, SW620, MCF7, Mouse liver, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1104-1328 of human MYBBP1A (NP_055335.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DLTV LLGV LQGQ QQSL QQGA HSTG SSRL HDLY WQAM KTLG VQRP KLEK KDAK EIPS ATQS PISK KRKK KGFL PETK KRKK RKSE DGTP AEDG TPAA TGGS QPPS MGRK KRNR TKAK VPAQ ANGT PTTK SPAP GAPT RSPS TPAK SPKL QKKN QKPS QVNG APGS PTEP AGQK QHQK ALPK KGVL GKSP LSAL ARKK ARLS LVIR SPSL LQSG AKKK AQVR KAGK P
Gene ID:10514
Uniprot:Q9BQG0
Cellular Location:Cytoplasm, Nucleus, nucleolus
Calculated MW:148kDa/149kDa
Observed MW:149kDa
UniProt Protein Function:MYBBP1A: may activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Binds to and represses JUN and MYB via the leucine zipper regions present in these proteins. Also binds to and represses PGC-1 (PPAR gamma coactivator-1): this interaction is abrogated when PGC-1 is phosphorylated by ERK1. Binds to and stimulates transcription by AhR. Binds to KPNA2. Shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on exportin 1. Predominantly nucleolar. Two alternatively spliced isoforms have been described.
UniProt Protein Details:

Protein type:Nucleolus; DNA replication; DNA-binding; RNA-binding

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: NLS-dependent protein nuclear import complex; intracellular membrane-bound organelle; membrane; cytoplasm; nucleolus; nucleus

Molecular Function:protein binding; sequence-specific DNA binding; DNA-directed DNA polymerase activity; transcription corepressor activity; transcription factor binding

Biological Process: osteoblast differentiation; cellular response to glucose starvation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; nucleocytoplasmic transport; circadian regulation of gene expression; negative regulation of transcription, DNA-dependent

NCBI Summary:This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
UniProt Code:Q9BQG0
NCBI GenInfo Identifier:71153825
NCBI Gene ID:10514
NCBI Accession:Q9BQG0.2
UniProt Secondary Accession:Q9BQG0,Q86VM3, Q9BW49, Q9P0V5, Q9UF99,
UniProt Related Accession:Q9BQG0
Molecular Weight:1328
NCBI Full Name:Myb-binding protein 1A
NCBI Synonym Full Names:MYB binding protein (P160) 1a
NCBI Official Symbol:MYBBP1A  
NCBI Official Synonym Symbols:P160; PAP2  
NCBI Protein Information:myb-binding protein 1A; p53-activated protein-2
UniProt Protein Name:Myb-binding protein 1A
Protein Family:Myb-binding protein
UniProt Gene Name:MYBBP1A  
UniProt Entry Name:MBB1A_HUMAN

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