Anti-MYBPC2 Antibody (CAB13331)

Antibody Name:	Anti-MYBPC2 Antibody
Antibody SKU:	CAB13331
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 912-1141 of human MYBPC2 (NP_004524.3).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	Mouse skeletal muscle, Rat skeletal muscle

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 912-1141 of human MYBPC2 (NP_004524.3).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	LSVQ IENM KDTA TIRI RVVE KAGP PINV MVKE VWGT NALV EWQA PKDD GNSE IMGY FVQK ADKK TMEW FNVY ERNR HTSC TVSD LIVG NEYY FRVY TENI CGLS DSPG VSKN TARI LKTG ITFK PFEY KEHD FRMA PKFL TPLI DRVV VAGY SAAL NCAV RGHP KPKV VWMK NKME IRED PKFL ITNY QGVL TLNI RRPS PFDA GTYT CRAV NELG EALA ECKL EVRV PQ
Gene ID:	4606
Uniprot:	Q14324
Cellular Location:
Calculated MW:	128kDa
Observed MW:	140kDa

Synonyms:

MYBPC2, MYBPC, MYBPCF, fast-type

Background:

This gene encodes a member of the myosin-binding protein C family. This family includes the fast-, slow- and cardiac-type isoforms, each of which is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The protein encoded by this locus is referred to as the fast-type isoform. Mutations in the related but distinct genes encoding the slow-type and cardiac-type isoforms have been associated with distal arthrogryposis, type 1 and hypertrophic cardiomyopathy, respectively.

UniProt Protein Function:	MYBPC2: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Belongs to the immunoglobulin superfamily. MyBP family.
UniProt Protein Details:	Protein type:Myosin-binding Chromosomal Location of Human Ortholog: 19q13.33 Cellular Component: cytosol Molecular Function:protein binding; structural constituent of muscle; actin binding Biological Process: cell adhesion; muscle filament sliding
NCBI Summary:	This gene encodes a member of the myosin-binding protein C family. This family includes the fast-, slow- and cardiac-type isoforms, each of which is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The protein encoded by this locus is referred to as the fast-type isoform. Mutations in the related but distinct genes encoding the slow-type and cardiac-type isoforms have been associated with distal arthrogryposis, type 1 and hypertrophic cardiomyopathy, respectively. [provided by RefSeq, Jul 2012]
UniProt Code:	Q14324
NCBI GenInfo Identifier:	296439237
NCBI Gene ID:	4606
NCBI Accession:	Q14324.2
UniProt Secondary Accession:	Q14324,A1L4G9,
UniProt Related Accession:	Q14324
Molecular Weight:	1141
NCBI Full Name:	Myosin-binding protein C, fast-type
NCBI Synonym Full Names:	myosin binding protein C, fast type
NCBI Official Symbol:	MYBPC2
NCBI Official Synonym Symbols:	MYBPC; MYBPCF
NCBI Protein Information:	myosin-binding protein C, fast-type; fast MyBP-C; C-protein, skeletal muscle fast isoform; fast-type muscle myosin-binding-protein C
UniProt Protein Name:	Myosin-binding protein C, fast-type
UniProt Synonym Protein Names:	C-protein, skeletal muscle fast isoform
Protein Family:	Myosin-binding protein
UniProt Gene Name:	MYBPC2
UniProt Entry Name:	MYPC2_HUMAN

	Western blot analysis of extracts of various cell lines, using MYBPC2 antibody (CAB13331) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
	Immunohistochemistry of paraffin-embedded human liver damage using MYBPC2 antibody (CAB13331) at dilution of 1:100 (40x lens).

Antibodies

Anti-MYBPC2 Antibody (CAB6934)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)