Anti-N-terminal Arginylation Antibody [11G1]

N-terminal Arginylation Antibody [11G1]

N-terminal Arginylation Antibody [11G1] is a mouse monoclonal antibody directed against N-terminal Arginylation, offered by Assay Genie for research applications. Reported applications include WB. Reactivity is species independent. Supplied as IgG3, purified by Protein G.

N-terminal arginylation is a conserved post-translational modification that adds arginine residues to proteins, primarily via the action of arginyltransferase ATE1. This modification plays a pivotal role in embryonic development, cytoskeletal regulation, and cellular stress responses. In the context of neurodegeneration, N-terminal arginylation is essential for maintaining neuronal proteostasis and responding to endoplasmic reticulum and oxidative stress. It facilitates the degradation of misfolded proteins and modulates the actin cytoskeleton, both of which are critical for synaptic function and neuronal survival. Disruption of arginylation pathways has been linked to neurodevelopmental disorders and may contribute to the progression of diseases such as ALS and Alzheimer’s. As such, N-terminal arginylation represents a promising avenue for therapeutic exploration in neuroscience. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.