Anti-N-terminal Arginylation Antibody [4D12]

N-terminal Arginylation Antibody [4D12]

N-terminal Arginylation Antibody [4D12] is a mouse monoclonal antibody directed against N-terminal Arginylation, offered by Assay Genie for research applications. Reported applications include WB. Reactivity is species independent. Supplied as IgG1, purified by Protein G.

Protein arginylation, specifically at the N-terminus, is a critical post-translational modification mediated by the enzyme ATE1. This process regulates protein turnover, stress response, and cytoskeletal organization. In neurons, N-terminal arginylation facilitates the clearance of misfolded proteins and modulates actin dynamics, both essential for synaptic integrity and plasticity. Emerging evidence suggests that dysregulation of arginylation contributes to neurodegenerative pathologies by impairing proteostasis and enhancing susceptibility to cellular stress. Arginylation also influences the unfolded protein response and autophagy, linking it to mechanisms underlying Alzheimer’s and Huntington’s disease. As a regulator of neuronal resilience and intracellular signaling, N-terminal arginylation is gaining attention as a potential therapeutic target in neurodegeneration. This antibody is also available conjugated to ATTO 390, ATTO 488, ATTO 594, APC, Biotin, FITC, HRP, PerCP and RPE. Supplied in 100 µg. For research use only; not for diagnostic or therapeutic procedures.