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Immunology Antibodies 3 Anti-NEDD4 Antibody CAB4385
Key Features

NEDD4 Rabbit Monoclonal Antibody (CAB4385)

Datasheet MSDS
SKU CAB4385
Product Type Antibody
Antibody Type Monoclonal Antibody
Reactivity Human
Host Species Rabbit
Synonyms RPF1, NEDD4-1, NEDD4
Research Use Immunology
€131 - €457

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Description

system_update_altDatasheetsystem_update_altMSDS

NEDD4 Monoclonal Antibody (CAB4385)

The NEDD4 Monoclonal Antibody (CAB4385) is a high-quality antibody developed for reliable detection and analysis of target proteins. This antibody, produced using rabbit monoclonal technology, exhibits high specificity and sensitivity for detecting NEDD4 in human samples, making it an ideal choice for Western blot assays. By targeting NEDD4, researchers can investigate its role in various cellular processes, including protein ubiquitination and degradation, and its potential implications in diseases such as cancer and neurological disorders.

This antibody is validated for use in WB, ELISA applications and has demonstrated reactivity against Human samples.

Product Name:NEDD4 Monoclonal Antibody
SKU:CAB4385
Size:20μL, 100μL
Reactivity:Human
Clone Number:ARC0992
Conjugate:Unconjugated
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Sequence:GDVD VNDW REHT KYKN GYSA NHQV IQWF WKAV LMMD SEKR IRLL QFVT GTSR VPMN GFAE LYGS NGPQ SFTV EQWG TPEK LPRA HTCF NRLD LPPY ESFE E
Tested Applications:WB ELISA
Recommended Dilution:
WB1:500 - 1:1000
ELISARecommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Synonyms:RPF1, NEDD4-1, NEDD4
Positive Sample:HeLa, SH-SY5Y
Cellular Localization:Cell Membrane, Cytoplasm, Peripheral Membrane Protein.
Calculated MW:149kDa
Observed MW:115kDa

This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN.

Purification MethodAffinity purification
Gene ID4734
RRIDAB_2863258
Buffer InformationStore at -20℃. Avoid freeze / thaw cycles. Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.
Product ImageWestern blot analysis of various lysates using NEDD4 Rabbit mAb (CAB4385) at 1:1000 dilution. Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25μg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (AbGn00020). Exposure time: 1s.
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