NFE2L2 Antibody (PACO05882)
- SKU:
- PACO05882
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | NFE2L2 Antibody (PACO05882) |
| Antibody SKU: | PACO05882 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | WB, IHC |
| Recommended Dilutions: | WB:1:500-1:2000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Recombinant Protein |
| Form: | Liquid |
| Storage Buffer: | PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol. |
| Purification Method: | Affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | Nrf2 |
| UniProt Protein Function: | NRF2: a transcription factor that regulates basal expression and antioxidant induction of a transcription factor for NAD(P)H:quinone oxidoreductase-1 (NQO1) and other detoxifying genes. Targeted for proteasomal degradation by INrf2. Oxidative stress causes its phosphorylation and release from INrf2. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 2q31.2 Cellular Component: centrosome; cytoplasm; cytosol; nucleus; plasma membrane Molecular Function:DNA binding; protein binding; protein domain specific binding; transcription factor activity Biological Process: positive regulation of transcription from RNA polymerase II promoter; proteasomal ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-independent protein catabolic process; protein ubiquitination; transcription from RNA polymerase II promoter; unfolded protein response |
| NCBI Summary: | This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015] |
| UniProt Code: | Q16236 |
| NCBI GenInfo Identifier: | 25453452 |
| NCBI Gene ID: | 4780 |
| NCBI Accession: | Q16236.3 |
| UniProt Secondary Accession: | Q16236,Q53RW6, Q59HH2, Q96F71, B2RBU2, B4E338, E9PGJ7 |
| UniProt Related Accession: | Q16236 |
| Molecular Weight: | 65,356 Da |
| NCBI Full Name: | Nuclear factor erythroid 2-related factor 2 |
| NCBI Synonym Full Names: | nuclear factor, erythroid 2 like 2 |
| NCBI Official Symbol: | NFE2L2 |
| NCBI Official Synonym Symbols: | NRF2; HEBP1 |
| NCBI Protein Information: | nuclear factor erythroid 2-related factor 2 |
| UniProt Protein Name: | Nuclear factor erythroid 2-related factor 2 |
| UniProt Synonym Protein Names: | HEBP1; Nuclear factor, erythroid derived 2, like 2 |
| UniProt Gene Name: | NFE2L2 |
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