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Anti-NKX3.1 Antibody (CAB19734)

SKU:
CAB19734
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
BAPX2
NKX3
NKX3.1
NKX3A
€139 - €419
Frequently bought together:

Description

Product Name:NKX3.1 Rabbit mAb
Product Code:CAB19734
Size:20uL, 50uL, 100uL
Synonyms:BAPX2, NKX3, NKX3.1, NKX3A
Applications:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human NKX3.1
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:A-549, DU145, PC-3
Immunogen:A synthesized peptide derived from human NKX3.1
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4824
Uniprot:Q99801
Calculated MW:32kDa
Observed MW:35KDa
UniProt Protein Function:NKX3-1: Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Play an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Act as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. Interacts with serum response factor (SRF). Interacts with SPDEF. Interacts with WDR77. Interacts with TOPORS which polyubiquitinates NKX3-1 and induces its proteasomal degradation. By androgens and, in the LNCAP cell line, by estrogens. Androgenic control may be lost in prostate cancer cells during tumor progression from an androgen-dependent to an androgen- independent phase. Highly expressed in the prostate and, at a lower level, in the testis. Belongs to the NK-3 homeobox family. 5 isoforms of the human protein are produced by alternative splicing.Protein type: Tumor suppressor; Transcription factor; DNA-bindingChromosomal Location of Human Ortholog: 8p21.2Cellular Component: intracellular; nucleusMolecular Function: androgen receptor activity; caspase activator activity; estrogen receptor activity; estrogen receptor binding; histone deacetylase binding; protein binding; protein kinase activator activity; protein self-association; sequence-specific DNA binding; transcription factor activity; transcription factor bindingBiological Process: androgen receptor signaling pathway; branching morphogenesis of a tube; caspase activation; multicellular organismal development; negative regulation of cell proliferation; negative regulation of epithelial cell proliferation; negative regulation of insulin-like growth factor receptor signaling pathway; negative regulation of mitotic cell cycle; negative regulation of transcription, DNA-dependent; positive regulation of caspase activity; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of mitotic cell cycle; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid phosphorylation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein kinase B signaling cascade; response to testosterone stimulus; salivary gland development
UniProt Protein Details:
NCBI Summary:This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012]
UniProt Code:Q99801
NCBI GenInfo Identifier:17377578
NCBI Gene ID:4824
NCBI Accession:Q99801.2
UniProt Secondary Accession:Q99801,O15465, Q9H2P4, Q9H2P5, Q9H2P6, Q9H2P7, Q9HBG0
UniProt Related Accession:Q99801
Molecular Weight:21,626 Da
NCBI Full Name:Homeobox protein Nkx-3.1
NCBI Synonym Full Names:NK3 homeobox 1
NCBI Official Symbol:NKX3-1  
NCBI Official Synonym Symbols:NKX3; BAPX2; NKX3A; NKX3.1  
NCBI Protein Information:homeobox protein Nkx-3.1
UniProt Protein Name:Homeobox protein Nkx-3.1
UniProt Synonym Protein Names:Homeobox protein NK-3 homolog A
Protein Family:Homeobox protein
UniProt Gene Name:NKX3-1  
UniProt Entry Name:NKX31_HUMAN

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