null

Anti-OPRL1 Antibody (CAB3113)

SKU:
CAB3113
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Developmental Biology
$167 - $503
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-OPRL1 Antibody
Antibody SKU:CAB3113
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide of human OPRL1
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:K-562, SW620, NCI-H460, U-87MG
Immunogen:A synthetic peptide of human OPRL1
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:4987
Uniprot:P41146
Cellular Location:Cell membrane, Cytoplasmic vesicle, Multi-pass membrane protein
Calculated MW:40kDa
Observed MW:50kDa
Synonyms:OPRL1, KOR-3, NOCIR, NOP, NOPr, OOR, ORL1
Background:The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon.
UniProt Protein Function:KOR-3: Receptor for the neuropeptide nociceptin/orphanin FQ. Has a potential role in modulating a number of brain functions, including instinctive behaviors and emotions. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 20q13.33

Cellular Component: neuron projection; integral to plasma membrane; cytoplasmic membrane-bound vesicle; plasma membrane

Molecular Function:G-protein coupled receptor activity; neuropeptide binding; protein binding; nociceptin/orphanin-FQ receptor activity

Biological Process: synaptic transmission; elevation of cytosolic calcium ion concentration; neuropeptide signaling pathway; sensory perception; behavior; G-protein signaling, adenylate cyclase inhibiting pathway; sensory perception of pain

NCBI Summary:The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
UniProt Code:P41146
NCBI GenInfo Identifier:730230
NCBI Gene ID:4987
NCBI Accession:P41146.1
UniProt Related Accession:P41146
Molecular Weight:
NCBI Full Name:Nociceptin receptor
NCBI Synonym Full Names:opioid related nociceptin receptor 1
NCBI Official Symbol:OPRL1  
NCBI Official Synonym Symbols:NOP; OOR; NOPr; ORL1; KOR-3; NOCIR  
NCBI Protein Information:nociceptin receptor
UniProt Protein Name:Nociceptin receptor
UniProt Synonym Protein Names:Kappa-type 3 opioid receptor; KOR-3; Orphanin FQ receptor
UniProt Gene Name:OPRL1  
UniProt Entry Name:OPRX_HUMAN
Anti-OPRL1 Antibody (CAB3113)Western blot analysis of extracts of various cell lines, using OPRL1 antibody (CAB3113) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021).

Related Products